Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

BACKGROUND: Uridine phosphorylase (UPP) is a key enzyme of pyrimidine salvage pathways, catalyzing the reversible phosphorolysis of ribosides of uracil to nucleobases and ribose 1-phosphate. It is also a critical enzyme in the activation of pyrimidine-based chemotherapeutic compounds such a 5-fluoro...

Descripción completa

Detalles Bibliográficos
Autores principales: Roosild, Tarmo P, Castronovo, Samantha, Fabbiani, Michael, Pizzorno, Giuseppe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664818/
https://www.ncbi.nlm.nih.gov/pubmed/19291308
http://dx.doi.org/10.1186/1472-6807-9-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664818/
https://www.ncbi.nlm.nih.gov/pubmed/19291308
http://dx.doi.org/10.1186/1472-6807-9-14

Ejemplares similares