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Copper(II) Binding to α-Synuclein, the Parkinson’s Protein
[Image: see text] Variations in tryptophan fluorescence intensities confirm that copper(II) interacts with α-synuclein, a protein implicated in Parkinson’s disease. Trp4 fluorescence decay kinetics measured for the F4W protein show that Cu(II) binds tightly (K(d) ∼ 100 nM) near the N-terminus at pH...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664836/ https://www.ncbi.nlm.nih.gov/pubmed/18465859 http://dx.doi.org/10.1021/ja711415b |