ARF6-Mediated Endosome Recycling Reverses Lipid Accumulation Defects in Niemann-Pick Type C Disease

In human Niemann-Pick Type C (NPC) disease, endosomal trafficking defects lead to an accumulation of free cholesterol and other lipids in late endosome/lysosome (LE/LY) compartments, a subsequent block in cholesterol esterification and significantly reduced cholesterol efflux out of the cell. Here w...

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Detalles Bibliográficos
Autores principales: Schweitzer, Jill Kuglin, Pietrini, Sean D., D'Souza-Schorey, Crislyn
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664925/
https://www.ncbi.nlm.nih.gov/pubmed/19365558
http://dx.doi.org/10.1371/journal.pone.0005193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664925/
https://www.ncbi.nlm.nih.gov/pubmed/19365558
http://dx.doi.org/10.1371/journal.pone.0005193

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