The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells

It has been stipulated that repair of clustered DNA lesions may be compromised, possibly leading to the formation of double-strand breaks (DSB) and, thus, to deleterious events. Using a variety of model multiply damaged sites (MDS), we investigated parameters that govern the formation of DSB during...

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Detalles Bibliográficos
Autores principales: Kozmin, Stanislav G., Sedletska, Yuliya, Reynaud-Angelin, Anne, Gasparutto, Didier, Sage, Evelyne
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665211/
https://www.ncbi.nlm.nih.gov/pubmed/19174565
http://dx.doi.org/10.1093/nar/gkp010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665211/
https://www.ncbi.nlm.nih.gov/pubmed/19174565
http://dx.doi.org/10.1093/nar/gkp010

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