Structural insights into TDP-43 in nucleic-acid binding and domain interactions

TDP-43 is a pathogenic protein: its normal function in binding to UG-rich RNA is related to cystic fibrosis, and inclusion of its C-terminal fragments in brain cells is directly linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Here we report the 1.65 Å crys...

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Detalles Bibliográficos
Autores principales: Kuo, Pan-Hsien, Doudeva, Lyudmila G., Wang, Yi-Ting, Shen, Che-Kun James, Yuan, Hanna S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665213/
https://www.ncbi.nlm.nih.gov/pubmed/19174564
http://dx.doi.org/10.1093/nar/gkp013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665213/
https://www.ncbi.nlm.nih.gov/pubmed/19174564
http://dx.doi.org/10.1093/nar/gkp013

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