Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

DNA single-strand breaks containing 3′-blocking groups are generated from attack of the sugar backbone by reactive oxygen species or after base excision by DNA glycosylase/apurinic/apyrimidinic (AP) lyases. In human cells, APE1 excises sugar fragments that block the 3′-ends thus facilitating DNA rep...

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Detalles Bibliográficos
Autores principales: Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Yang, Wei, González-Pacanowska, Dolores, Vidal, Antonio E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665217/
https://www.ncbi.nlm.nih.gov/pubmed/19181704
http://dx.doi.org/10.1093/nar/gkp021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665217/
https://www.ncbi.nlm.nih.gov/pubmed/19181704
http://dx.doi.org/10.1093/nar/gkp021

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