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AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity
Retrotransposons make up over 40% of the mammalian genome. Some copies are still capable of mobilizing and new insertions promote genetic variation. Several members of the APOBEC3 family of DNA cytosine deaminases function to limit the replication of a variety of retroelements, such as the long-term...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665220/ https://www.ncbi.nlm.nih.gov/pubmed/19188259 http://dx.doi.org/10.1093/nar/gkp030 |