A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4

The DNA structure-selective endonuclease Mus81-Mms4/Eme1 incises a number of nicked joint molecule substrates in vitro. 3′-flaps are an excellent in vitro substrate for Mus81-Mms4/Eme1. Mutants in MUS81 are synthetically lethal with mutations in the 5′-flap endonuclease FEN1/Rad27 in Saccharomyces c...

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Detalles Bibliográficos
Autores principales: Ehmsen, Kirk Tevebaugh, Heyer, Wolf-Dietrich
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665226/
https://www.ncbi.nlm.nih.gov/pubmed/19211663
http://dx.doi.org/10.1093/nar/gkp038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665226/
https://www.ncbi.nlm.nih.gov/pubmed/19211663
http://dx.doi.org/10.1093/nar/gkp038

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