Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions

Long-term treatment with the anticancer and immunosuppressant thiopurines, azathioprine or 6-mercaptopurine, is associated with acute skin sensitivity to ultraviolet A (UVA) radiation and a high risk of skin cancer. 6-thioguanine (6-TG) that accumulates in the DNA of thiopurine-treated patients inte...

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Detalles Bibliográficos
Autores principales: Brem, Reto, Li, Feng, Karran, Peter
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665240/
https://www.ncbi.nlm.nih.gov/pubmed/19208641
http://dx.doi.org/10.1093/nar/gkp070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665240/
https://www.ncbi.nlm.nih.gov/pubmed/19208641
http://dx.doi.org/10.1093/nar/gkp070

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