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Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions
Long-term treatment with the anticancer and immunosuppressant thiopurines, azathioprine or 6-mercaptopurine, is associated with acute skin sensitivity to ultraviolet A (UVA) radiation and a high risk of skin cancer. 6-thioguanine (6-TG) that accumulates in the DNA of thiopurine-treated patients inte...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665240/ https://www.ncbi.nlm.nih.gov/pubmed/19208641 http://dx.doi.org/10.1093/nar/gkp070 |