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The transcription factor ThPOK acts late in helper T cell lineage specification and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
The transcription factor ThPOK has been shown to be required and sufficient for CD4(+)CD8(−) thymocyte generation, yet the mechanism through which ThPOK orchestrates CD4 helper T cell lineage differentiation remains unclear. Here we utilized reporter mice to track expression of transcription factors...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666788/ https://www.ncbi.nlm.nih.gov/pubmed/18776905 http://dx.doi.org/10.1038/ni.1652 |