Cargando…

Unc119 Protects from Shigella Infection by Inhibiting the Abl Family Kinases

BACKGROUND: Bacteria engage cell surface receptors and intracellular signaling molecules to enter the cell. Unc119 is an adaptor protein, which interacts with receptors and tyrosine kinases. Its role in bacterial invasion of cells is unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used biochemical, mole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vepachedu, Ramarao, Karim, Zunayet, Patel, Ojas, Goplen, Nicholas, Alam, Rafeul
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667249/ https://www.ncbi.nlm.nih.gov/pubmed/19381274 http://dx.doi.org/10.1371/journal.pone.0005211

Ejemplares similares

Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation
por: Gorska, Magdalena M., et al.
Publicado: (2004)

unc-119 mutants have an increased fungal spore adhesion that is not rescued by Cb-unc-119
por: Omi, Shizue, et al.
Publicado: (2021)

Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation
por: Konitsiotis, Antonios D., et al.
Publicado: (2017)

20 Years of unc-119 as a transgene marker
por: Maduro, Morris F
Publicado: (2015)

A Novel Role for UNC119 as an Enhancer of Synaptic Transmission
por: Fehlhaber, Katherine E., et al.
Publicado: (2023)

FRI617 Targeting Unc119b For Insulin Sensitization
por: Mittal, Ayushi, et al.
Publicado: (2023)

SapTrap vectors for introducing point mutations with unc-119+ selection
por: Schwartz, Matthew, et al.
Publicado: (2018)

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119
por: Cromm, Philipp M., et al.
Publicado: (2019)

The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms
por: Yelland, Tamas, et al.
Publicado: (2021)

UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis
por: Lee, YuKyung, et al.
Publicado: (2013)

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119
por: Zhang, Qing, et al.
Publicado: (2016)

Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans
por: Adamla, Frauke, et al.
Publicado: (2015)

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
por: Sánchez-Bellver, Laura, et al.
Publicado: (2022)

UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting
por: Drozd, Cody J., et al.
Publicado: (2023)

TbUNC119 and Its Binding Protein Complex Are Essential for Propagation, Motility, and Morphogenesis of Trypanosoma brucei Procyclic Form Cells
por: Ohshima, Shigeru, et al.
Publicado: (2010)

UNC119 is a binding partner of tumor suppressor Ras‐association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53
por: Iwasa, Hiroaki, et al.
Publicado: (2018)

$^{119}$Sn Mössbauer study of the implantation behaviour of $^{119}$In, $^{119}$Sn, $^{119m}$Sn, $^{119}$Sb and $^{119m}$Te ions in SiC
por: Petersen, J W, et al.
Publicado: (1985)

The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP
por: Norris, Adam D., et al.
Publicado: (2014)

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration
por: May, Stephanie, et al.
Publicado: (2014)

Tools for Mos1-mediated single copy insertion (mosSCI) with excisable unc-119(+) or NeoR (G418) selection cassettes
por: Aram, Reta, et al.
Publicado: (2019)

The decay of $]^{119}$Cd and $\^{119}$In isomers
por: Scheidemann, O, et al.
Publicado: (1976)

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
por: Caylor, Raymond C, et al.
Publicado: (2013)

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways
por: MacNeil, Lesley T., et al.
Publicado: (2009)

MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation
por: Gorska, Magdalena M., et al.
Publicado: (2007)

Lyn, Jak2, and Raf-1 Kinases Are Critical for the Antiapoptotic Effect of Interleukin 5, whereas only Raf-1 Kinase Is Essential for Eosinophil Activation and Degranulation
por: Pazdrak, Konrad, et al.
Publicado: (1998)

Abl Family Kinases Regulate Endothelial Barrier Function In Vitro and in Mice
por: Chislock, Elizabeth M., et al.
Publicado: (2013)

Regulation of MT dynamics via direct binding of an Abl family kinase
por: Hu, Yuhan, et al.
Publicado: (2019)

Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity
por: Ng, Khong Y., et al.
Publicado: (2014)

$\beta$ and $\gamma$-spectroscopy study of $^{119}$Pd and $^{119}$Ag
por: Kurpeta, J, et al.
Publicado: (2022)

Src- and Abl-family kinases activate spleen tyrosine kinase to maximize phagocytosis and Leishmania infection
por: Ullah, Imran, et al.
Publicado: (2023)

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I
por: Mian, Afsar Ali, et al.
Publicado: (2012)

Unc-51-like kinase (ULK) complex-independent autophagy induced by hypoxia
por: Feng, Yan, et al.
Publicado: (2018)

Klaviertücke Op.119
por: Brahms, Johannes, 1833-1897
Publicado: (1976)

Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma
por: Wu, Qinjuan, et al.
Publicado: (2023)

Large-Scale Production of (119m)Te and (119)Sb for Radiopharmaceutical Applications
por: Bennett, Kevin T., et al.
Publicado: (2019)

UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity
por: Wang, Zheng, et al.
Publicado: (2014)

Two alleles of unc-52 locus disrupting potential cell-binding motif of UNC-52
por: Wilsey, Rachel, et al.
Publicado: (2020)

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
por: Pooryasin, Atefeh, et al.
Publicado: (2021)

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex
por: Kang, Yunlu, et al.
Publicado: (2022)

Mössbauer study of $^{119}$Sn defects in silicon from ion implantations of radioactive $^{119}$In
por: Weyer, G, et al.
Publicado: (1980)

Cannot write session to /tmp/vufind_sessions/sess_otgi5rgfea227a05vqdcl1qst4