Elevated P75(NTR )expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression

BACKGROUND: The homeodomain transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic (mesDA) neurons in a cell-autonomous and gene-dose-dependent manner. Homozygote mutant mice, deficient of both genes (En1-/-;En2-/-), die at birth and exhibit a l...

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Detalles Bibliográficos
Autores principales: Alavian, Kambiz N, Sgadò, Paola, Alberi, Lavinia, Subramaniam, Srinivasa, Simon, Horst H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667502/
https://www.ncbi.nlm.nih.gov/pubmed/19291307
http://dx.doi.org/10.1186/1749-8104-4-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667502/
https://www.ncbi.nlm.nih.gov/pubmed/19291307
http://dx.doi.org/10.1186/1749-8104-4-11

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