VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo

Von Hippel-Lindau (VHL) disease is caused by germline mutations in the VHL tumor suppressor gene, with Type 2B missense VHL mutations predisposing to renal cell carcinoma, hemangioblastoma, and pheochromocytoma. Type 2B mutant pVHL is predicted to be defective in hypoxia inducible factor (HIF)-α reg...

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Detalles Bibliográficos
Autores principales: Lee, C M, Hickey, M, Sanford, C A, McGuire, C G, Cowey, C L, Simon, M C, Rathmell, W K
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667565/
https://www.ncbi.nlm.nih.gov/pubmed/19252526
http://dx.doi.org/10.1038/onc.2009.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667565/
https://www.ncbi.nlm.nih.gov/pubmed/19252526
http://dx.doi.org/10.1038/onc.2009.12

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