The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch

DEXD/H-box RNA helicases couple ATP hydrolysis to RNA remodeling by an unknown mechanism. We used x-ray crystallography and biochemical analysis of the human DEXD/H-box protein DDX19 to investigate its regulatory mechanism. The crystal structures of DDX19, in its RNA-bound prehydrolysis and free pos...

Descripción completa

Detalles Bibliográficos
Autores principales: Collins, Ruairi, Karlberg, Tobias, Lehtiö, Lari, Schütz, Patrick, van den Berg, Susanne, Dahlgren, Lars-Göran, Hammarström, Martin, Weigelt, Johan, Schüler, Herwig
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Accelerated Publication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667716/
https://www.ncbi.nlm.nih.gov/pubmed/19244245
http://dx.doi.org/10.1074/jbc.C900018200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667716/
https://www.ncbi.nlm.nih.gov/pubmed/19244245
http://dx.doi.org/10.1074/jbc.C900018200

Ejemplares similares