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The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch

DEXD/H-box RNA helicases couple ATP hydrolysis to RNA remodeling by an unknown mechanism. We used x-ray crystallography and biochemical analysis of the human DEXD/H-box protein DDX19 to investigate its regulatory mechanism. The crystal structures of DDX19, in its RNA-bound prehydrolysis and free pos...

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Detalles Bibliográficos
Autores principales:	Collins, Ruairi, Karlberg, Tobias, Lehtiö, Lari, Schütz, Patrick, van den Berg, Susanne, Dahlgren, Lars-Göran, Hammarström, Martin, Weigelt, Johan, Schüler, Herwig
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Accelerated Publication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667716/ https://www.ncbi.nlm.nih.gov/pubmed/19244245 http://dx.doi.org/10.1074/jbc.C900018200

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