Unexpected Hepatotoxicity of Rifampin and Saquinavir/Ritonavir in Healthy Male Volunteers

OBJECTIVES: Rifampin is a potent inducer of the cytochrome P450 3A4 isoenzyme (CYP3A4) that metabolizes most protease inhibitor (PI) antiretrovirals. This study was designed to evaluate the steady-state pharmacokinetics and tolerability of the coadministration of the PIs saquinavir and ritonavir (a...

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Detalles Bibliográficos
Autores principales: Schmitt, Christophe, Riek, Myriam, Winters, Katie, Schutz, Malte, Grange, Susan
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667892/
https://www.ncbi.nlm.nih.gov/pubmed/19381336
http://dx.doi.org/10.1111/j.1753-5174.2009.00017.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667892/
https://www.ncbi.nlm.nih.gov/pubmed/19381336
http://dx.doi.org/10.1111/j.1753-5174.2009.00017.x

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