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Unexpected Hepatotoxicity of Rifampin and Saquinavir/Ritonavir in Healthy Male Volunteers

OBJECTIVES: Rifampin is a potent inducer of the cytochrome P450 3A4 isoenzyme (CYP3A4) that metabolizes most protease inhibitor (PI) antiretrovirals. This study was designed to evaluate the steady-state pharmacokinetics and tolerability of the coadministration of the PIs saquinavir and ritonavir (a...

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Detalles Bibliográficos
Autores principales:	Schmitt, Christophe, Riek, Myriam, Winters, Katie, Schutz, Malte, Grange, Susan
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Inc 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667892/ https://www.ncbi.nlm.nih.gov/pubmed/19381336 http://dx.doi.org/10.1111/j.1753-5174.2009.00017.x

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