The overexpression of major antioxidant enzymes does not extend the lifespan of mice

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the ove...

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Detalles Bibliográficos
Autores principales: Pérez, Viviana I, Van Remmen, Holly, Bokov, Alex, Epstein, Charles J, Vijg, Jan, Richardson, Arlan
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667893/
https://www.ncbi.nlm.nih.gov/pubmed/19077044
http://dx.doi.org/10.1111/j.1474-9726.2008.00449.x
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author Pérez, Viviana I
Van Remmen, Holly
Bokov, Alex
Epstein, Charles J
Vijg, Jan
Richardson, Arlan
author_facet Pérez, Viviana I
Van Remmen, Holly
Bokov, Alex
Epstein, Charles J
Vijg, Jan
Richardson, Arlan
author_sort Pérez, Viviana I
collection PubMed
description We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.
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spelling pubmed-26678932009-04-17 The overexpression of major antioxidant enzymes does not extend the lifespan of mice Pérez, Viviana I Van Remmen, Holly Bokov, Alex Epstein, Charles J Vijg, Jan Richardson, Arlan Aging Cell Short Take We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice. Blackwell Publishing Ltd 2009-02 2008-11-25 /pmc/articles/PMC2667893/ /pubmed/19077044 http://dx.doi.org/10.1111/j.1474-9726.2008.00449.x Text en © 2009 The Authors. Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2009
spellingShingle Short Take
Pérez, Viviana I
Van Remmen, Holly
Bokov, Alex
Epstein, Charles J
Vijg, Jan
Richardson, Arlan
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
title The overexpression of major antioxidant enzymes does not extend the lifespan of mice
title_full The overexpression of major antioxidant enzymes does not extend the lifespan of mice
title_fullStr The overexpression of major antioxidant enzymes does not extend the lifespan of mice
title_full_unstemmed The overexpression of major antioxidant enzymes does not extend the lifespan of mice
title_short The overexpression of major antioxidant enzymes does not extend the lifespan of mice
title_sort overexpression of major antioxidant enzymes does not extend the lifespan of mice
topic Short Take
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667893/
https://www.ncbi.nlm.nih.gov/pubmed/19077044
http://dx.doi.org/10.1111/j.1474-9726.2008.00449.x
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