Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

BACKGROUND: Hypocatabolism of the amyloid β-protein (Aβ) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been established whether the proteolytic activity o...

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Detalles Bibliográficos
Autores principales: Cabrol, Christelle, Huzarska, Malwina A., Dinolfo, Christopher, Rodriguez, Maria C., Reinstatler, Lael, Ni, Jake, Yeh, Li-An, Cuny, Gregory D., Stein, Ross L., Selkoe, Dennis J., Leissring, Malcolm A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668070/
https://www.ncbi.nlm.nih.gov/pubmed/19384407
http://dx.doi.org/10.1371/journal.pone.0005274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668070/
https://www.ncbi.nlm.nih.gov/pubmed/19384407
http://dx.doi.org/10.1371/journal.pone.0005274

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