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Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramide...

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Detalles Bibliográficos
Autores principales: Nakayama, Takayuki, Matsushita, Tadashi, Yamamoto, Koji, Mutsuga, Noriko, Kojima, Tetsuhito, Katsumi, Akira, Nakao, Norihiko, Sadler, J. Evan, Naoe, Tomoki, Saito, Hidehiko
Formato: Texto
Lenguaje:English
Publicado: Springer Japan 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668596/
https://www.ncbi.nlm.nih.gov/pubmed/18369690
http://dx.doi.org/10.1007/s12185-008-0065-8