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Efficient retroviral transduction of human B-lymphoid and myeloid progenitors: marked inhibition of their growth by the Pax5 transgene

We applied a coculture system for the genetic manipulation of human B-lymphoid and myeloid progenitor cells using murine bone marrow stromal cell support, and investigated the effects of forced Pax5 expression in both cell types. Cytokine-stimulated cord blood CD34(+) cells could be transduced at 85...

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Detalles Bibliográficos
Autores principales: Sekine, Rieko, Kitamura, Toshio, Tsuji, Takashi, Tojo, Arinobu
Formato: Texto
Lenguaje:English
Publicado: Springer Japan 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668641/
https://www.ncbi.nlm.nih.gov/pubmed/18415655
http://dx.doi.org/10.1007/s12185-008-0082-7