Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains

BACKGROUND: Immature bone marrow B cells are known to have longer CDR3 than mature peripheral B cells, and this genetic characteristic has been shown to correlate with autoreactivity in these early cells. B-cell Central tolerance eliminates these cells, but it is known that autoreactive B cells neve...

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Detalles Bibliográficos
Autores principales: Volpe, Joseph M, Kepler, Thomas B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669064/
https://www.ncbi.nlm.nih.gov/pubmed/19250530
http://dx.doi.org/10.1186/1745-7580-5-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669064/
https://www.ncbi.nlm.nih.gov/pubmed/19250530
http://dx.doi.org/10.1186/1745-7580-5-1

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