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Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms

BACKGROUND: The fidelity of DNA replication serves as the nidus for both genetic evolution and genomic instability fostering disease. Single nucleotide polymorphisms (SNPs) constitute greater than 80% of the genetic variation between individuals. A new theory regarding DNA replication fidelity has e...

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Detalles Bibliográficos
Autores principales:	Arehart, Eric, Gleim, Scott, White, Bill, Hwa, John, Moore, Jason H
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669078/ https://www.ncbi.nlm.nih.gov/pubmed/19331672 http://dx.doi.org/10.1186/1756-0381-2-2

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