A Modeling-Derived Hypothesis on Chronicity in Respiratory Diseases: Desensitized Pathogen Recognition Secondary to Hyperactive IRAK/TRAF6 Signaling

Several chronic respiratory diseases exhibit hyperactive immune responses in the lung: abundant inflammatory mediators; infiltrating neutrophils, macrophages, lymphocytes and other immune cells; and increased level of proteases. Such diseases include cystic fibrosis (CF), chronic obstructive pulmona...

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Detalles Bibliográficos
Autores principales: Zhang, Tingting, Song, Kyung W., Hekmat-Nejad, Mohammad, Morris, David G., Wong, Brian R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669711/
https://www.ncbi.nlm.nih.gov/pubmed/19390631
http://dx.doi.org/10.1371/journal.pone.0005332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669711/
https://www.ncbi.nlm.nih.gov/pubmed/19390631
http://dx.doi.org/10.1371/journal.pone.0005332

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