A Structure-Based Approach to Ligand Discovery for 2C-Methyl-d-erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy

[Image: see text] The nonmevalonate route to isoprenoid biosynthesis is essential in Gram-negative bacteria and apicomplexan parasites. The enzymes of this pathway are absent from mammals, contributing to their appeal as chemotherapeutic targets. One enzyme, 2C-methyl-d-erythritol-2,4-cyclodiphospha...

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Detalles Bibliográficos
Autores principales: Ramsden, Nicola L., Buetow, Lori, Dawson, Alice, Kemp, Lauris A., Ulaganathan, Venkatsubramanian, Brenk, Ruth, Klebe, Gerhard, Hunter, William N.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669732/
https://www.ncbi.nlm.nih.gov/pubmed/19320487
http://dx.doi.org/10.1021/jm801475n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669732/
https://www.ncbi.nlm.nih.gov/pubmed/19320487
http://dx.doi.org/10.1021/jm801475n

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