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Application of Homozygosity Haplotype Analysis to Genetic Mapping with High-Density SNP Genotype Data
BACKGROUND: In families segregating a monogenic genetic disorder with a single disease gene introduction, patients share a mutation-carrying chromosomal interval with identity-by-descent (IBD). Such a shared chromosomal interval or haplotype, surrounding the actual pathogenic mutation, is typically...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670504/ https://www.ncbi.nlm.nih.gov/pubmed/19399176 http://dx.doi.org/10.1371/journal.pone.0005280 |