Efficient Second Strand Cleavage during Holliday Junction Resolution by RuvC Requires Both Increased Junction Flexibility and an Exposed 5′ Phosphate

BACKGROUND: Holliday junction (HJ) resolution is a critical step during homologous recombination. In Escherichia coli this job is performed by a member of the RNase H/Integrase superfamily called RuvC, whereas in Schizosaccharomyces pombe it has been attributed to the XPF family member Mus81-Eme1. H...

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Detalles Bibliográficos
Autores principales: Osman, Fekret, Gaskell, Louise, Whitby, Matthew C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670506/
https://www.ncbi.nlm.nih.gov/pubmed/19399178
http://dx.doi.org/10.1371/journal.pone.0005347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670506/
https://www.ncbi.nlm.nih.gov/pubmed/19399178
http://dx.doi.org/10.1371/journal.pone.0005347

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