Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models

BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by hamartomatous growths in the brain, skin, kidneys, lungs, and heart, which lead to significant morbidity. TSC is caused by mutations in the TSC1 or TSC2 genes, whose products, hamartin a...

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Detalles Bibliográficos
Autores principales: Lee, Nancy, Woodrum, Chelsey L, Nobil, Alison M, Rauktys, Aubrey E, Messina, Michael P, Dabora, Sandra L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670829/
https://www.ncbi.nlm.nih.gov/pubmed/19368729
http://dx.doi.org/10.1186/1471-2210-9-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670829/
https://www.ncbi.nlm.nih.gov/pubmed/19368729
http://dx.doi.org/10.1186/1471-2210-9-8

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