Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay

BACKGROUND: Fluoroquinolones are extensively used antibiotics that induce DNA double-strand breaks (DSBs) by trapping DNA gyrase and topoisomerase IV on DNA. This effect is usually evaluated using biochemical or molecular procedures, but these are not effective at the single-cell level. We assessed...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamayo, María, Santiso, Rebeca, Gosalvez, Jaime, Bou, Germán, Fernández, José Luis
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670838/
https://www.ncbi.nlm.nih.gov/pubmed/19364397
http://dx.doi.org/10.1186/1471-2180-9-69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670838/
https://www.ncbi.nlm.nih.gov/pubmed/19364397
http://dx.doi.org/10.1186/1471-2180-9-69

Ejemplares similares