Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression

OBJECTIVE: The cytokine interleukin-6 (IL-6) stimulates AMP-activated protein kinase (AMPK) and insulin signaling in skeletal muscle, both of which result in the activation of endothelial nitric oxide synthase (eNOS). We hypothesized that IL-6 promotes endothelial cell signaling and capillary recrui...

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Detalles Bibliográficos
Autores principales: Yuen, Derek Y.C., Dwyer, Renee M., Matthews, Vance B., Zhang, Lei, Drew, Brian G., Neill, Bronwyn, Kingwell, Bronwyn A., Clark, Michael G., Rattigan, Stephen, Febbraio, Mark A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671037/
https://www.ncbi.nlm.nih.gov/pubmed/19188427
http://dx.doi.org/10.2337/db08-0775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671037/
https://www.ncbi.nlm.nih.gov/pubmed/19188427
http://dx.doi.org/10.2337/db08-0775

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