Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

OBJECTIVE: GPR40 is a G protein–coupled receptor regulating free fatty acid–induced insulin secretion. We generated transgenic mice overexpressing the hGPR40 gene under control of the mouse insulin II promoter and used them to examine the role of GPR40 in the regulation of insulin secretion and gluc...

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Detalles Bibliográficos
Autores principales: Nagasumi, Kae, Esaki, Ritsuko, Iwachidow, Kimihiko, Yasuhara, Yoshitaka, Ogi, Kazuhiro, Tanaka, Hideyuki, Nakata, Mitsugu, Yano, Takashi, Shimakawa, Kozo, Taketomi, Shigehisa, Takeuchi, Koji, Odaka, Hiroyuki, Kaisho, Yoshihiko
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671040/
https://www.ncbi.nlm.nih.gov/pubmed/19401434
http://dx.doi.org/10.2337/db08-1233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671040/
https://www.ncbi.nlm.nih.gov/pubmed/19401434
http://dx.doi.org/10.2337/db08-1233

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