Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans

OBJECTIVE: The evolutionary conservation of transcriptional mechanisms has been widely exploited to understand human biology and disease. Recent findings, however, unexpectedly showed that the transcriptional regulators hepatocyte nuclear factor (HNF)-1α and -4α rarely bind to the same genes in mice...

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Detalles Bibliográficos
Autores principales: Boj, Sylvia F., Servitja, Joan Marc, Martin, David, Rios, Martin, Talianidis, Iannis, Guigo, Roderic, Ferrer, Jorge
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671044/
https://www.ncbi.nlm.nih.gov/pubmed/19188435
http://dx.doi.org/10.2337/db08-0812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671044/
https://www.ncbi.nlm.nih.gov/pubmed/19188435
http://dx.doi.org/10.2337/db08-0812

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