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Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

OBJECTIVE: The Sec1/Munc18 protein Munc18c has been implicated in Syntaxin 4–mediated exocytosis events, although its purpose in exocytosis has remained elusive. Given that Syntaxin 4 functions in the second phase of glucose-stimulated insulin secretion (GSIS), we hypothesized that Munc18c would als...

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Detalles Bibliográficos
Autores principales: Oh, Eunjin, Thurmond, Debbie C.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671048/
https://www.ncbi.nlm.nih.gov/pubmed/19188424
http://dx.doi.org/10.2337/db08-1059