Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance

OBJECTIVE: Insulin resistance develops in tandem with obesity. Ablating myostatin (Mstn) prevents obesity, so we investigated if Mstn deficiency could improve insulin sensitivity. A loss-of-function mutation (Mstn(Ln)) in either one or both alleles of the Mstn gene shows how Mstn deficiency protects...

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Detalles Bibliográficos
Autores principales: Wilkes, Jason J., Lloyd, David J., Gekakis, Nick
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671051/
https://www.ncbi.nlm.nih.gov/pubmed/19208906
http://dx.doi.org/10.2337/db08-0245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671051/
https://www.ncbi.nlm.nih.gov/pubmed/19208906
http://dx.doi.org/10.2337/db08-0245

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