GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

OBJECTIVE: Intestinal L-cells secrete the incretin glucagon-like peptide-1 (GLP-1) in response to ingestion of nutrients, especially long-chain fatty acids. The Gαs-coupled receptor GPR119 binds the long-chain fatty acid derivate oleoylethanolamide (OEA), and GPR119 agonists enhance GLP-1 secretion....

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Detalles Bibliográficos
Autores principales: Lauffer, Lina M., Iakoubov, Roman, Brubaker, Patricia L.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671052/
https://www.ncbi.nlm.nih.gov/pubmed/19208912
http://dx.doi.org/10.2337/db08-1237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671052/
https://www.ncbi.nlm.nih.gov/pubmed/19208912
http://dx.doi.org/10.2337/db08-1237

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