Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

OBJECTIVE: We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and d...

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Detalles Bibliográficos
Autores principales: Wong, F. Susan, Khai Siew, Lai, Scott, Gwen, Thomas, Ian J., Chapman, Stephen, Viret, Christophe, Wen, Li
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671054/
https://www.ncbi.nlm.nih.gov/pubmed/19208910
http://dx.doi.org/10.2337/db08-0800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671054/
https://www.ncbi.nlm.nih.gov/pubmed/19208910
http://dx.doi.org/10.2337/db08-0800

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