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Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

OBJECTIVE: We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and d...

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Detalles Bibliográficos
Autores principales:	Wong, F. Susan, Khai Siew, Lai, Scott, Gwen, Thomas, Ian J., Chapman, Stephen, Viret, Christophe, Wen, Li
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671054/ https://www.ncbi.nlm.nih.gov/pubmed/19208910 http://dx.doi.org/10.2337/db08-0800

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