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A Differential Wiring Analysis of Expression Data Correctly Identifies the Gene Containing the Causal Mutation

Transcription factor (TF) regulation is often post-translational. TF modifications such as reversible phosphorylation and missense mutations, which can act independent of TF expression level, are overlooked by differential expression analysis. Using bovine Piedmontese myostatin mutants as proof-of-c...

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Detalles Bibliográficos
Autores principales: Hudson, Nicholas J., Reverter, Antonio, Dalrymple, Brian P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671163/
https://www.ncbi.nlm.nih.gov/pubmed/19412532
http://dx.doi.org/10.1371/journal.pcbi.1000382