Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides

Antisense oligonucleotides (AOs) have been shown to induce dystrophin expression in muscles cells of patients with Duchenne Muscular Dystrophy (DMD) and in the mdx mouse, the murine model of DMD. However, ineffective delivery of AOs limits their therapeutic potential. Copolymers of cationic poly(eth...

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Detalles Bibliográficos
Autores principales: Sirsi, Shashank R, Schray, Rebecca C, Wheatley, Margaret A, Lutz, Gordon J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671478/
https://www.ncbi.nlm.nih.gov/pubmed/19351396
http://dx.doi.org/10.1186/1477-3155-7-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671478/
https://www.ncbi.nlm.nih.gov/pubmed/19351396
http://dx.doi.org/10.1186/1477-3155-7-1

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