Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

Glycogen synthase kinase 3 (GSK-3) dysregulation is implicated in the two Alzheimer's disease (AD) pathological hallmarks: β-amyloid plaques and neurofibrillary tangles. GSK-3 inhibitors may abrogate AD pathology by inhibiting amyloidogenic γ-secretase cleavage of amyloid precursor protein (APP...

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Detalles Bibliográficos
Autores principales: Rezai-Zadeh, Kavon, Douglas Shytle, R, Bai, Yun, Tian, Jun, Hou, Huayan, Mori, Takashi, Zeng, Jin, Obregon, Demian, Town, Terrence, Tan, Jun
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671567/
https://www.ncbi.nlm.nih.gov/pubmed/18410522
http://dx.doi.org/10.1111/j.1582-4934.2008.00344.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671567/
https://www.ncbi.nlm.nih.gov/pubmed/18410522
http://dx.doi.org/10.1111/j.1582-4934.2008.00344.x

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