Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

The mammalian Sonic hedgehog (Shh) signalling pathway is essential for embryonic development and the patterning of multiple organs. Disruption or activation of Shh signalling leads to multiple birth defects, including holoprosencephaly, neural tube defects and polydactyly, and in adults results in t...

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Detalles Bibliográficos
Autores principales: Patterson, Victoria L., Damrau, Christine, Paudyal, Anju, Reeve, Benjamin, Grimes, Daniel T., Stewart, Michelle E., Williams, Debbie J., Siggers, Pam, Greenfield, Andy, Murdoch, Jennifer N.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671985/
https://www.ncbi.nlm.nih.gov/pubmed/19223390
http://dx.doi.org/10.1093/hmg/ddp075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671985/
https://www.ncbi.nlm.nih.gov/pubmed/19223390
http://dx.doi.org/10.1093/hmg/ddp075

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