Improvement of Morphine-Mediated Analgesia by Inhibition of β-Arrestin 2 Expression in Mice Periaqueductal Gray Matter

Morphine is a well-known μ-opioid receptor (MOR) agonist and an efficient analgesic, but its long-term use inevitably leads to drug addiction and tolerance. Here, we show that specific inhibition of β-arrestin2 with its siRNA lentivirus microinjected in mice periaqueductal gray matter (PAG) signific...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yuting, Liu, Xing, Liu, Chang, Kang, Jiuhong, Yang, Jingyu, Pei, Gang, Wu, Chunfu
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672012/
https://www.ncbi.nlm.nih.gov/pubmed/19399231
http://dx.doi.org/10.3390/ijms10030954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672012/
https://www.ncbi.nlm.nih.gov/pubmed/19399231
http://dx.doi.org/10.3390/ijms10030954

Ejemplares similares