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High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors
BACKGROUND: Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic. Particularly, short-lasting painful sensations have been reported upon dermal application of morphine. To study a possible involvemen...
Autores principales: | Forster, Alexander B, Reeh, Peter W, Messlinger, Karl, Fischer, Michael JM |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672059/ https://www.ncbi.nlm.nih.gov/pubmed/19371406 http://dx.doi.org/10.1186/1744-8069-5-17 |
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