Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells

PURPOSE: Oxidative stress is a risk factor for the onset and progression of primary open-angle glaucoma (POAG), but the exact molecular basis remains unknown. Here, we investigated the mechanisms for Pro370Leu mutant myocilin to induce mitochondrial dysfunction and subsequent reactive oxygen species...

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Detalles Bibliográficos
Autores principales: He, Yuan, Leung, Kar Wah, Zhuo, Ye-Hong, Ge, Jian
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672150/
https://www.ncbi.nlm.nih.gov/pubmed/19390644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672150/
https://www.ncbi.nlm.nih.gov/pubmed/19390644

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