Dosage Effects of Cohesin Regulatory Factor PDS5 on Mammalian Development: Implications for Cohesinopathies

Cornelia de Lange syndrome (CdLS), a disorder caused by mutations in cohesion proteins, is characterized by multisystem developmental abnormalities. PDS5, a cohesion protein, is important for proper chromosome segregation in lower organisms and has two homologues in vertebrates (PDS5A and PDS5B). Pd...

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Detalles Bibliográficos
Autores principales: Zhang, Bin, Chang, Jufang, Fu, Ming, Huang, Jie, Kashyap, Rakesh, Salavaggione, Ezequiel, Jain, Sanjay, Shashikant, Kulkarni, Deardorff, Matthew A., Uzielli, Maria L. Giovannucci, Dorsett, Dale, Beebe, David C., Jay, Patrick Y., Heuckeroth, Robert O., Krantz, Ian, Milbrandt, Jeffrey
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672303/
https://www.ncbi.nlm.nih.gov/pubmed/19412548
http://dx.doi.org/10.1371/journal.pone.0005232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672303/
https://www.ncbi.nlm.nih.gov/pubmed/19412548
http://dx.doi.org/10.1371/journal.pone.0005232

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