Solution structure of DNA containing α-OH-PdG: the mutagenic adduct produced by acrolein

Acrolein is a cell metabolic product and a main component of cigarette smoke. Its reaction with DNA produces two guanine lesions γ-OH-PdG, a major adduct that is nonmutagenic in mammalian cells, and the positional isomer α-OH-PdG. We describe here the solution structure of a short DNA duplex contain...

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Detalles Bibliográficos
Autores principales: Zaliznyak, Tanya, Bonala, Rahda, Attaluri, Sivaprasad, Johnson, Francis, de los Santos, Carlos
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673425/
https://www.ncbi.nlm.nih.gov/pubmed/19223332
http://dx.doi.org/10.1093/nar/gkp076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673425/
https://www.ncbi.nlm.nih.gov/pubmed/19223332
http://dx.doi.org/10.1093/nar/gkp076

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