Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

Expression of a proof-reading deficient form of mitochondrial DNA (mtDNA) polymerase γ, POLG, causes early death accompanied by features of premature ageing in mouse. However, the mechanism of cellular senescence remains unresolved. In addition to high levels of point mutations of mtDNA, the POLG mu...

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Detalles Bibliográficos
Autores principales: Bailey, Laura J., Cluett, Tricia J., Reyes, Aurelio, Prolla, Tom A., Poulton, Joanna, Leeuwenburgh, Christiaan, Holt, Ian J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673436/
https://www.ncbi.nlm.nih.gov/pubmed/19244310
http://dx.doi.org/10.1093/nar/gkp091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673436/
https://www.ncbi.nlm.nih.gov/pubmed/19244310
http://dx.doi.org/10.1093/nar/gkp091

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