Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

BACKGROUND: GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on...

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Detalles Bibliográficos
Autores principales: Maneechotesuwan, Kittipong, Yao, Xin, Ito, Kazuhiro, Jazrawi, Elen, Usmani, Omar S., Adcock, Ian M., Barnes, Peter J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674207/
https://www.ncbi.nlm.nih.gov/pubmed/19436703
http://dx.doi.org/10.1371/journal.pmed.1000076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674207/
https://www.ncbi.nlm.nih.gov/pubmed/19436703
http://dx.doi.org/10.1371/journal.pmed.1000076

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