HAC stability in murine cells is influenced by nuclear localization and chromatin organization

BACKGROUND: Human artificial chromosomes (HAC) are small functional extrachromosomal elements, which segregate correctly during each cell division. In human cells, they are mitotically stable, however when the HAC are transferred to murine cells they show an increased and variable rate of loss. In s...

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Detalles Bibliográficos
Autores principales: Moralli, Daniela, Chan, David YL, Jefferson, Andrew, Volpi, Emanuela V, Monaco, Zoia L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674426/
https://www.ncbi.nlm.nih.gov/pubmed/19267891
http://dx.doi.org/10.1186/1471-2121-10-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674426/
https://www.ncbi.nlm.nih.gov/pubmed/19267891
http://dx.doi.org/10.1186/1471-2121-10-18

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